Journal: Neuropsychologia

Article Title: Neural Substrates of Spontaneous Narrative Production in Focal Neurodegenerative Disease

doi: 10.1016/j.neuropsychologia.2015.10.022

Figure Lengend Snippet: Patterns of grey matter loss in storytelling group analyses compared to controls, adjusting for age, gender, and total intracranial volume (TIV). All results are presented at a threshold of pFWE P<0.001 uncorrected. Images were overlaid with MRIcron (http://http://www.mccauslandcenter.sc.edu/CRNL/) on an average brain based on the healthy older control gray matter template used for DARTEL warping.

Article Snippet: Both stages were performed using the SPM8 software package, using the intrinsic DARTEL toolbox for warping (Wellcome Department of Cognitive Neurology, London; http://www.fil.ion.ucl.ac.uk/spm/ running on Matlab 7.0.1 (MathWorks, Natick, MA), using a template derived from 320 healthy older control participants.

Techniques:

Journal: Cell reports

Article Title: Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

doi: 10.1016/j.celrep.2024.115056

Figure Lengend Snippet: WT ( Vim +/+ Foxp3 YFP-Cre ) and vimentin cKO ( Vim fl/fl Foxp3 YFP-Cre ) mice were intratracheally infected with lethal (60 plaque-forming units [PFUs]) (A) or a sublethal (30 PFUs) (A–K) dose of IAV. (A) Survival curve for WT ( n = 15, lethal; n = 9, sublethal) and vimentin cKO ( n = 9, lethal; n = 8, sublethal) mice using log rank (Mantel-Cox) test. (B) Percentage of weight loss from baseline in WT ( n = 8) and vimentin cKO ( n = 10) mice, analyzed by mixed-effects model with Sidak’s multiple comparisons test. Data are mean ± SEM. (C) Representative H&E lung staining at 21 dpi. Scale bar, 100 μm. (D) Lung injury score from H&E sections. (E) CD45 staining of lungs at 21 dpi. Scale bar, 100 μm. (F) Flow cytometry quantification of CD45 + cells from whole lung at 21 dpi. (G) Krt5 and Foxp3 staining of lungs at 21 dpi. Scale bars, 100 μm (bright field) and 50 μm (fluorescence). (H and I) Quantification of Krt5 expression (H) and frequency (I) using TissueGnostics HistoQuest. (J) IFN-β levels in BALF by multiplex immunoassay ( n = 3–8 mice per group). (K) Viral titer of whole-lung homogenates at 5 dpi. Data are mean ± SD, n = 4–6 mice per group. p values were calculated by two-way ANOVA (B and J) and two-tailed unpaired Student’s t test (D, F, H, I, and K). NS, not significant ( p > 0.05), * p < 0.05, ** p < 0.005, and **** p < 0.0001.

Article Snippet: HistoQuest 7.0.1.0153 , TissueGnostics , https://tissuegnostics.com/.

Techniques: Infection, Staining, Flow Cytometry, Fluorescence, Expressing, Multiplex Assay, Two Tailed Test

Journal: Cell reports

Article Title: Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

doi: 10.1016/j.celrep.2024.115056

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: HistoQuest 7.0.1.0153 , TissueGnostics , https://tissuegnostics.com/.

Techniques: Purification, Blocking Assay, Plasmid Preparation, Functional Assay, Control, Virus, Recombinant, Avidin-Biotin Assay, Cell Isolation, Enzyme-linked Immunosorbent Assay, Software